A mole is a unit of measurement used in chemistry to express amounts of a chemical substance. One mole of a substance is defined as the amount of substance that contains Avogadro’s number of entities. Avogadro’s number is defined as the number of entities (atoms, molecules, ions, etc.) in one mole of a substance and has a value of 6.022 x 10^23 entities/mole. This allows chemists to calculate the number of entities in a sample of a substance by using the relationship between the mass of the substance and Avogadro’s number. See the detailed explanation by Science is Lit in the video.

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